Blar i forfatter "Klingenberg, Claus Andreas"

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    • Analysis of Antibiotic Exposure and Early-Onset Neonatal Sepsis in Europe, North America, and Australia 

      Giannoni, Eric; Dimopoulou, Varvara; Klingenberg, Claus Andreas; Navér, Lars; Nordberg, Viveka; Berardi, Alberto; El Helou, Salhab; Fusch, Gerhard; Bliss, Joseph M.; Lehnick, Dirk; Guerina, Nicholas; Seliga-Siwecka, Joanna; Maton, Pierre; Lagae, Donatienne; Mari, Judit; Janota, Jan; Agyeman, Philipp K A; Pfister, Riccardo; Latorre, Giuseppe; Maffei, Gianfranco; Laforgia, Nicola; Mózes, Eniko; Størdal, Ketil; Strunk, Tobias; Stocker, Martin (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-23)
      <p><b> IMPORTANCE</b> Appropriate use of antibiotics is life-saving in neonatal early-onset sepsis (EOS), but overuse of antibiotics is associated with antimicrobial resistance and long-term adverse outcomes. Large international studies quantifying early-life antibiotic exposure along with EOS incidence are needed to provide a basis for future interventions aimed at safely reducing neonatal ...

    • Antibiotic therapy in neonates and impact on gut microbiota and antibiotic resistance development: a systematic review 

      Fjalstad, Jon Widding; Esaiassen, Eirin; Juvet, Lene Kristine; van den Anker, John; Klingenberg, Claus Andreas (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-22)
      <p><i>Objectives - </i>To systematically review the impact of antibiotic therapy in the neonatal period on changes in the gut microbiota and/or antibiotic resistance development. <p><i>Methods - </i>Data sources were PubMed, Embase, Medline and the Cochrane Database, supplemented by manual searches of reference lists. Randomized controlled trials (RCTs) and observational studies were included if ...

    • Antibiotic Use in Term and Near-Term Newborns 

      Mundal, Håkon S.; Rønnestad, Arild Erland; Klingenberg, Claus Andreas; Stensvold, Hans Jørgen; Størdal, Ketil (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-01)
      OBJECTIVES - We aimed to study whether national and local antibiotic stewardship projects have reduced the antibiotic use in newborns and to monitor potential changes in adverse outcomes.<p> <p>METHODS - In a nationwide, population-based study from Norway, we included all hospital live births from 34 weeks' gestation (n = 282 046) during 2015 to 2019. The primary outcome was the proportion of ...

    • Core genome conservation of Staphylococcus haemolyticus limits sequence based population structure analysis 

      Cavanagh, Jorunn Pauline; Klingenberg, Claus Andreas; Hanssen, Anne-Merethe; Aarag, Elizabeth; Francois, Patrice; Schrenzel, Jaques; Flægstad, Trond; Sollid, Johanna U Ericson (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      The notoriously multi-resistant Staphylococcus haemolyticus is an emerging pathogen causing serious infections in immunocompromised patients. Defining the population structure is important to detect outbreaks and spread of antimicrobial resistant clones. Currently, the standard typing technique is pulsed-field gel electrophoresis (PFGE). In this study we describe novel molecular typing schemes for ...

    • Delivery Room ST Segment Analysis to Predict Short Term Outcomes in Near-Term and Term Newborns 

      Linde, Jørgen Erland; Solevåg, Anne Lee; Eilevstjønn, Joar; Blacy, Ladislaus; Kidanto, Hussein; Ersdal, Hege Langli; Klingenberg, Claus Andreas (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-03)
      Background: ST-segment changes to the fetal electrocardiogram (ECG) may indicate fetal acidosis. No large-scale characterization of ECG morphology immediately after birth has been performed, but ECG is used for heart rate (HR) assessment. We aimed to investigate ECG morphology immediately after birth in asphyxiated infants, using one-lead dry-electrode ECG developed for HR measurement. Methods: ...

    • Development of early life gut resistome and mobilome across gestational ages and microbiota-modifying treatments 

      Bargheet, Ahmed; Klingenberg, Claus Andreas; Esaiassen, Eirin; Hjerde, Erik; Cavanagh, Jorunn Pauline; Bengtsson-Palme, Johan; Pettersen, Veronika K. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-13)
      Background - Gestational age (GA) and associated level of gastrointestinal tract maturation are major factors driving the initial gut microbiota composition in preterm infants. Besides, compared to term infants, premature infants often receive antibiotics to treat infections and probiotics to restore optimal gut microbiota. How GA, antibiotics, and probiotics modulate the microbiota’s core ...

    • Early empirical antibiotics and adverse clinical outcomes in infants born very preterm: A population-based cohort 

      Vatne, Anlaug; Hapnes, Nina; Stensvold, Hans Jørgen; Dalen, Ingvild; Guthe, Hans Jørgen Timm; Støen, Ragnhild; Brigtsen, Anne Karin; Rønnestad, Arild Erland; Klingenberg, Claus Andreas (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-28)
      Objective The objective of this study was to evaluate the association between empirical antibiotic therapy in the first postnatal week in uninfected infants born very preterm and the risk of adverse outcomes until discharge.<p> <p>Study design Population-based, nationwide registry study in Norway including all live-born infants with a gestational age <32 weeks surviving first postnatal week without ...

    • Early surfactant and non-invasive ventilation versus intubation and surfactant: a propensity score-matched national study 

      Reigstad, Hallvard; Hufthammer, Karl Ove; Rønnestad, Arild Erland; Klingenberg, Claus Andreas; Stensvold, Hans Jørgen; Markestad, Trond Jacob (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-27)
      <p><b> Objective</b> To compare outcome after less invasive surfactant administration (LISA) and primary endotracheal intubation (non-LISA) in infants born before gestational age (GA) 28 weeks. <p><b> Setting</b> All neonatal intensive care units (NICUs) in Norway during 2012–2018. <p><b> Methods</b> Defined population-based data were prospectively entered into a national registry. We ...

    • Hofteleddsdysplasi hos spedbarn – screening, behandling og oppfølging 

      Laborie, Lene Bjerke; Klingenberg, Claus Andreas; Rasmussen, Hanne; Gundersen, Trude; Rosendahl, Karen (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-19)
      Hofteleddsdysplasi forkommer hos opptil 3 % av nyfødte og kan ubehandlet føre til luksert hofteledd, osteoartritt og behov for hofteprotese. Målet med studien var å kartlegge rutiner for ultralydscreening, behandling og oppfølging av hofteleddsdysplasi ved norske sykehus.

    • Kidney biopsy diagnosis in childhood in the Norwegian Kidney Biopsy Registry and the long-term risk of kidney replacement therapy: a 25-year follow-up 

      Gjerstad, Ann Christin; Skrunes, Rannveig; Tøndel, Camilla; Åsberg, Anders; Leh, Sabine; Klingenberg, Claus Andreas; Døllner, Henrik; Hammarström, Clara Louise; Bjerre, Anna Kristina (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-22)
      Background There is scarce information on biopsy-verifed kidney disease in childhood and its progression to chronic kidney disease stage 5 (CKD 5). This study aims to review biopsy fndings in children, and to investigate risk of kidney replacement therapy (KRT).<p> <p>Methods We conducted a retrospective long-term follow-up study of children included in the Norwegian Kidney Biopsy Registry (NKBR) ...

    • Late-onset sepsis in very preterm infants in Norway in 2009-2018: A population-based study 

      Huncikova, Zuzana; Vatne, Anlaug; Stensvold, Hans Jørgen; Lang, Astri Maria; Støen, Ragnhild; Brigtsen, Anne Karin; Salvesen, Bodil; Øymar, Knut Asbjørn Alexander; Rønnestad, Arild Erland; Klingenberg, Claus Andreas (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-02)
      Objective To evaluate epidemiology and outcomes among very preterm infants (<32 weeks’ gestation) with culture-positive and culture-negative late-onset sepsis (LOS).<p> <p>Design Cohort study using a nationwide, population-based registry. <p>Setting 21 neonatal units in Norway. <p>Participants All very preterm infants born 1 January 2009–31 December 2018 and admitted to a neonatal ...

    • Less is more: Antibiotics at the beginning of life 

      Stocker, Martin; Klingenberg, Claus Andreas; Navér, Lars; Nordberg, Viveka; Berardi, Alberto; el Helou, Salhab; Fusch, Gerhard; Bliss, Joseph M.; Lehnick, Dirk; Dimopoulou, Varvara; Guerina, Nicholas; Seliga-Siwecka, Joanna; Maton, Pierre; Lagae, Donatienne; Mari, Judit; Janota, Jan; Agyeman, Philipp K. A.; Pfister, Riccardo; Latorre, Giuseppe; Maffei, Gianfranco; Laforgia, Nichola; Mózes, Enikő; Størdal, Ketil; Strunk, Tobias; Giannoni, Eric (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-27)
      Antibiotic exposure at the beginning of life can lead to increased antimicrobial resistance and perturbations of the developing microbiome. Early-life microbiome disruption increases the risks of developing chronic diseases later in life. Fear of missing evolving neonatal sepsis is the key driver for antibiotic overtreatment early in life. Bias (a systemic deviation towards overtreatment) and noise ...

    • Meticillinresistente gule stafylokokker i sårsekret hos barn 

      Thaulow, Christian Magnus; Lindemann, Paul Christoffer; Klingenberg, Claus Andreas (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-07)
      BAKGRUNN - Hud- og bløtvevsinfeksjoner er vanlig hos barn. Vi ønsket å undersøke forekomsten av meticillinresistens blant gule stafylokokker i sårsekret fra barn i Norge.<p> <p>MATERIALE OG METODE - Vi gjennomførte en observasjonsstudie basert på data fra Norsk overvåkingssystem for antibiotikaresistens hos mikrober (NORM) for perioden 2013–21. Resistensdata fra sårsekret med vekst av gule ...

    • Neonatal Impedance Cardiography in Asphyxiated Piglets-A Feasibility Study 

      Berisha, Gazmend; Solberg, Rønnaug; Klingenberg, Claus Andreas; Solevåg, Anne Lee (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-25)
      Objectives: Impedance cardiography (ICG) is a non-invasive method for continuous cardiac output measurement and has the potential to improve monitoring and treatment of sick neonates. PhysioFlow® is a signal-morphology ICG-system showing promising results in adults with low and high cardiac output, but no data from neonates or neonatal models exist. The aim of this study was to investigate PhysioFlow® ...

    • Neonatal sepsis: a systematic review of core outcomes from randomised clinical trials 

      Henry, Cían J.; Semova, Gergana; Barnes, Ellen; Cotter, Isabel; Devers, Tara; Rafaee, Aisyah; Slavescu, Andreea; Cathain, Niamh O.; McCollum, Danielle; Roche, Edna; Mockler, David; Allen, John; Meehan, Judith; Klingenberg, Claus Andreas; Latour, Jos M.; van den Hoogen, Agnes; Strunk, Tobias; Giannoni, Eric; Schlapbach, Luregn J.; Degtyareva, Marina; Plötz, Frans B.; de Boode, Willem P.; Naver, Lars; Wynn, James L.; Küster, Helmut; Janota, Jan; Keij, Fleur M.; Reiss, Irwin K. M.; Bliss, Joseph M.; Polin, Richard; Koenig, Joyce M.; Turner, Mark A.; Gale, Christopher; Molloy, Eleanor J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-07)
      BACKGROUND: The lack of a consensus definition of neonatal sepsis and a core outcome set (COS) proves a substantial impediment to research that influences policy and practice relevant to key stakeholders, patients and parents.<p> <p>METHODS: A systematic review of the literature was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. ...

    • Nordic survey showed wide variation in discharge practices for very preterm infants 

      Arwehed, Sofia; Axelin, Anna; Björklund, Lars J.; Thernström Blomqvist, Ylva; Heiring, Christian; Jonsson, Baldvin; Klingenberg, Claus Andreas; Metsäranta, Marjo; Ågren, Johan; Lehtonen, Liisa (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-04)
      Aim: We aimed to describe clinical practices and criteria for discharge of very preterm infants in Nordic neonatal units.<p> <p>Methods: Medical directors of all 89 level-2 and level-3 units in Denmark, Finland, Iceland, Norway and Sweden were invited by e-mail to complete a web-based multiple-choice survey with the option to make additional free-text comments. <p>Results: We received responses ...

    • Predictors of extubation success: a population-based study of neonates below a gestational age of 26 weeks 

      Ohnstad, Mari Oma; Stensvold, Hans Jørgen; Pripp, Are Hugo; Tvedt, Christine Raaen; Jelsness-Jørgensen, Lars-Petter; Astrup, Henriette; Eriksen, Beate Horsberg; Klingenberg, Claus Andreas; Mreihil, Khalaf; Pedersen, Tanja; Rettedal, Siren; Selberg, Terje Reidar; Solberg, Rønnaug; Støen, Ragnhild; Rønnestad, Arild Erland (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-09)
      Objective The aim of the study was to investigate first extubation attempts among extremely premature (EP) infants and to explore factors that may increase the quality of clinical judgement of extubation readiness. Design and method A population-based study was conducted to explore first extubation attempts for EP infants born before a gestational age (GA) of 26 weeks in Norway between 1 January ...

    • Preterm birth in the Nordic countries—Capacity, management and outcome in neonatal care 

      Norman, Mikael; Padkær Petersen, Jesper; Stensvold, Hans Jørgen; Thorkelsson, Thordur; Helenius, Kjell; Brix Andersson, Charlotte; Ørum Cueto, Heidi; Domellöf, Magnus; Gissler, Mika; Heino, Anna; Håkansson, Stellan; Jonsson, Baldvin; Klingenberg, Claus Andreas; Lehtonen, Liisa; Metsäranta, Marjo; Rønnestad, Arild Erland; Trautner, Simon; Vatne, Anlaug; Støen, Ragnhild; Brække, Kristin; Reigstad, Hallvard (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-13)
      Aim - Organisation of care, perinatal and neonatal management of very preterm infants in the Nordic regions were hypothesised to vary significantly. The aim of this observational study was to test this hypothesis.<p> <p>Methods - Information on preterm infants in the 21 greater healthcare regions of Denmark, Finland, Iceland, Norway and Sweden was gathered from national registers in 2021. Preterm ...

    • Prophylactic Oropharyngeal Surfactant for Preterm Newborns at Birth: A Randomized Clinical Trial 

      Murphy, Madeleine C.; Miletin, Jan; Klingenberg, Claus Andreas; Guthe, Hans Jørgen Timm; Rigo, Vincent; Plavka, Richard; Bohlin, Kajsa; Barroso Pereira, Almerinda; Juren, Tomáš; Alih, Ekele; Galligan, Marie; O'Donnell, Colm P. F. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-11)
      Importance - Preterm newborns at risk of respiratory distress syndrome are supported with continuous positive airway pressure (CPAP). Many newborns worsen despite CPAP and are intubated for surfactant administration, an effective therapy for treatment of respiratory distress syndrome. Endotracheal intubation is associated with adverse effects. Pharyngeal administration of surfactant to preterm animals ...

    • Serumkonsentrasjonsmåling av gentamicin hos barn 

      Grodås, Karolina Teresa Maulen; Døllner, Henrik; Thaulow, Christian Magnus; Knudsen, Per Kristian; Tønnessen, Anders; Skeibrok, Mari; Klingenberg, Claus Andreas (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-16)
      BAKGRUNN<p> <p>Gentamicin brukes ofte ved alvorlige infeksjoner hos barn. Det har værtrutine i Norge å måle serumkonsentrasjon av gentamicin re før andre ellertredje dose (0-prøve) for å vurdere risiko fortoksisitet. Den kliniske betydningen av slike målinger hos barn ertidligere ikke evaluert i Norge. <p>MATERIALE OG METODE <p>Dee er en retrospektiv studie av rutinemessig utførte 0-prøverfor måling ...